vNi

Neurosyphilis refers to a site of infection involving the central nervous system (CNS). Neurosyphilis may occur at any stage of syphilis. Before the advent of antibiotics, it was typically seen in 25-35% of patients with syphilis.

Neurosyphilis occurs about 10 to 20 years after first being infected with syphilis. It is considered a life-threatening complication of syphilis. Not everyone who has syphilis will develop this complication.

There are four different forms of neurosyphilis:

* Asymptomatic
* Meningovascular
* Tabes dorsalis
* General paresis

Asymptomatic neurosyphilis occurs before symptomatic syphilis. Signs of the disease may be seen in the spinal fluid, but the person has no symptoms.

Meningovascular neurosyphilis causes nerve and eye problems, among other symptoms. There may be damage to the blood vessels, which can lead to a stroke.

Persons with tabes dorsalis have damage to the spinal cord that slowly gets worse, making them unable to walk.

In general paresis, brain cell damage causes paralysis, tremors, seizures, and mental decline. Inflammation may occur anywhere in the brain or spinal cord and can lead to a number of neurological problems.

* Headache
* Stiff neck
* Irritability
* Poor concentration
* Mental confusion
* Depression
* Visual disturbances
* Abnormal reflexes
* Abnormal gait (walk)
* Incontinence
* Dementia
* Weakness, numbness of lower extremities
* Loss of muscle function
* Muscle contractions
* Muscle atrophy

Note: There may be no symptoms

First, William Shakespeare wrote, in The Life of Timon of Athens, referencing the venereal nature of syphilis:

This fell whore of thine
Hath in her more destruction than thy sword,
For all her cherubim look."

Second, Isaac Asimov wrote in Limericks, under "Luetic Lament,":

There was a young man of Back Bay
Who thought syphilis just went away.
And thought that a chancre
Was merely a canker
Acquired in lascivious play.
Now first he got acne vulgaris,
The kind that is rampant in Paris
It covered his skin
From forehead to shin
And now people ask where his hair is.
With symptoms increasing in number,
His aorta's in need of a plumber
His hear is cavorting
His wife is aborting
And now he's acquired a gumma.
Consider his terrible plight -
His eyes won't react to the light
His hands are apraxic.His gait is ataxic.
He's developing gun-barrel sight.
His passions are strong as before
But his penis is flaccid, and sore.
His wife now has tabes
And sabre-shinned babies
She's really worse off than a whore.
There are pains in his belly and knees.
His sphincters have gone by degrees.
Paroxysmal incontinence,
With all its concomitants,
Brings on quite unpredictable pees.
Though treated in every known way,
His spirochetes grow day by day.
He's developed paresis,
Converses with Jesus,
And thinks he's the Queen of the May."

This poetic manifest reveals the myriad of sickening phenomenon arising from this chronic, indolent infection.